FIGURE

Figure 2

ID

ZDB-FIG-210417-9

Publication

Magnani et al., 2021 - uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

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Figure 2

dnmt1 and uhrf1 loss causes overexpression of retrotransposons. RNAseq analysis of Transposable Elements in uhrf1^−/− and dnmt1^−/− mutant livers. (A) MA plot showing log₂ fold change of repetitive elements in dnmt1^−/− livers calculated on WT siblings and Base Mean in WT siblings. Repetitive elements are divided by Class in DNA transposons (yellow), LTR (purple), LINE (light blue), SINE (blue), and other (gray). (B) MA plot showing log₂ fold change of repetitive elements in uhrf1^−/− livers calculated on WT siblings and Base Mean in WT siblings. Repetitive elements are divided by Class in DNA transposons (yellow), LTR (purple), LINE (light blue), SINE (blue), and other (gray). (C) Bar graph of Transposable Elements divided by class in uhrf1^−/− and dnmt1^−/− mutant livers. Upregulated TEs have log₂ fold change > 0 and downregulated TEs have log₂ fold change < 0. (D) Correlation plot of repetitive elements in uhrf1^−/− and dnmt1^−/− mutant livers. Upregulated TEs have adj as pedix < 0.05 and log₂ fold change > 0; downregulated TEs have p_adj < 0.05 and log₂ fold change < 0. Log₂ fold change is calculated between mutants and their own WT siblings.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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