FIGURE

Figure 1

ID

ZDB-FIG-210403-20

Publication

Castro et al., 2021 - Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design

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Figure 1

Expression levels of hoxd13a putative targets in hoxd13a-overexpressing fins (hoxd13+++) and controls (Wt) analyzed by RT-qPCR (B,C,E) and ISH (D,F,G). (A) Central role of the transcription factor Hoxd13 in the distal patterning of tetrapod limbs, based in Salsi and colleagues⁶. (B)meis1b appears downregulation in hoxd13+++ fins in comparison with Wt at 85 and 115 hpf. (C,D)dachA presents higher expression in hoxd13+++ fins than in Wt controls at 56 and 85 hpf (C) and is ectopically expressed in the distal margin of the transgenic fins at 85hpf (arrows), under the remaining finfold (FF) (D). (E,F) Expression analyses of bmp2a, bmp2b, bmp4, bmp7a, and bmp7b reveal upregulation of bmp2b and bmp7b in hoxd13+++ fins (E), which are ectopically expressed in the remaining finfold. Statistical significance evaluated by unpaired t-test: *p < 0.05; **p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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