ZFIN ID: ZDB-FIG-210325-48
Xia et al., 2019 - Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway. FEBS letters   593(15):2008-2018 Full text @ FEBS Lett.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibody:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Long-pec
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Long-pec to Day 5

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP s356tTg + MO2-top2b standard conditions Long-pec neuromast hair cell IFL
s356tTg + MO3-top2b standard conditions Long-pec neuromast hair cell IFL
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab11-sox2 IHC s356tTg + MO2-top2b standard conditions Long-pec neuromast support cell
IHC s356tTg + MO3-top2b standard conditions Long-pec neuromast support cell
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO2-top2b standard conditions Day 5 hair cell stereocilium decreased amount, abnormal
Day 5 hair cell stereocilium decreased length, abnormal
Day 5 hair cell stereocilium decreased thickness, abnormal
AB + MO3-top2b standard conditions Day 5 hair cell stereocilium decreased amount, abnormal
Day 5 hair cell stereocilium decreased length, abnormal
Day 5 hair cell stereocilium decreased thickness, abnormal
s356tTg + MO2-top2b standard conditions Long-pec neuromast decreased amount, abnormal
Long-pec neuromast decreased size, abnormal
Long-pec neuromast hair cell decreased amount, abnormal
Long-pec neuromast support cell decreased amount, abnormal
s356tTg + MO3-top2b standard conditions Long-pec neuromast decreased amount, abnormal
Long-pec neuromast decreased size, abnormal
Long-pec neuromast hair cell decreased amount, abnormal
Long-pec neuromast support cell decreased amount, abnormal
Full text @ FEBS Lett.