FIGURE

FIGURE 3

ID

ZDB-FIG-210321-5

Publication

Han et al., 2021 - Deficiency in Neuroserpin Exacerbates CoCl₂ Induced Hypoxic Injury in the Zebrafish Model by Increased Oxidative Stress

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FIGURE 3

Neuroserpin deficient zebrafish showed reduced locomotor activities and more neurons loss in diencephalon area under CoCl₂ induced hypoxic injury. (A) Representative graph for distance traveled in 40 min for WT and serpini1^−/− zebrafish. (B) Quantification of average distance moved per minute in WT and serpini1^−/− under 10 mM CoCl₂ induced injury. The data are presented as the mean ± SEM, n = 96 per group. Statistical analyses were performed with Student’s t-test, ***p < 0.001, ns: no significant, compared with WT in the same CoCl₂ concentration. (C) Images of neurons in diencephalon in Tg (Huc: RFP) and Tg (serpini1^−/−-HuC: RFP) under 10 mM CoCl₂ induced injury. Scale bar:100 um. (D) Quantification of average fluorescence intensity of neurons in diencephalon area in Tg (Huc: RFP) and Tg (serpini1^−/−-HuC: RFP) under 10 mM CoCl₂ induced injury. The data are presented as the mean ± SEM, n = 6 per group. Statistical analyses were performed with Student’s t-test, **p < 0.01, ns: no significant, compared with WT in the same CoCl₂ concentration.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	serpini1^{zf3527/zf3527} serpini1^{zf3527/zf3527}; fdu101Tg
Condition:	chemical treatment by environment: cobalt dichloride
Observed In:	diencephalon neuron locomotory behavior
Stage Range:	Day 4 to Day 5

Phenotype Detail

Acknowledgments

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