FIGURE

Fig. 3

ID

ZDB-FIG-210311-10

Publication

Castellanos et al., 2021 - Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish

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Fig. 3

Early neural crest cell (NCC) migration and specification are normal in morphants. a-a’ Non-injected (NI) Tg(sox10:TagRFP) larvae and hspg2 morpholino injected Tg(sox10:TagRFP) larvae (MO) (N = 6 and N = 4, respectively) were staged and fixed at the 18-somite stage. Images are scaled at 200 μm and demonstrate two lateral streams of Sox10⁺ migrating NCCs. b-b′ NI and MO larvae (N = 8 and N = 16 respectively) were staged and fixed at the Prim-5 stage. Images are scaled at 200 μm and demonstrate Sox10⁺ NCCs in the pharyngeal arches. No significant changes were found between the two groups at either timepoint. Schematic represents the two migratory NCC streams in a zebrafish larvae at 18 somites and the localization of the CNCCs in the four pharyngeal arches at the Prim-5 stage

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	co26Tg + MO4-hspg2
Knockdown Reagent:	MO4-hspg2
Observed In:	neural crest cell migration
Stage Range:	14-19 somites to Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.