FIGURE

Fig. 5

ID

ZDB-FIG-210302-11

Publication

Banks et al., 2021 - Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA

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Fig. 5

Figure 5. Transcriptional Profiling of tet Mutant Neutrophils Reveals Reduced Cytokine Response in tet3^−/− and tet2/3^DM Analysis of RNA sequencing from sorted neutrophils of 35-hpf wild-type, 2-dpf wild-type, 2-dpf tet2^−/−, 2-dpf tet3^−/−, and 2-dpf tet2/3^DM embryos. (A) Principal component analysis for all samples, with three independent biological samples representing each genotype, as indicated by colored circles. (B) Enriched GO terms related to hematopoiesis in genes downregulated in 2-dpf tet2/3^DM samples compared to 2-dpf wild-type samples. (C) Volcano plot comparing 2-dpf tet3^−/− and wild-type samples; the top 20 dysregulated genes are labeled. (D) Top 10 hallmark GSEA terms downregulated comparing 2-dpf tet3^−/− and wild-type samples; categories involved in cytokine response are highlighted in red. (E) Volcano plot comparing 2-dpf tet2/3^DM and wild-type samples; the top 20 dysregulated genes are labeled. (F) Top 10 hallmark GSEA terms downregulated comparing 2-dpf tet2/3^DM and wild-type samples; categories involved in cytokine response are highlighted in red.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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