FIGURE

Fig. 5

ID

ZDB-FIG-210218-104

Publication

Cao et al., 2021 - Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration

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Fig. 5

Obvious differences in calcineurin activity between the PCE and ACE. (A) The qRT-PCR analysis revealed that the ppp3ca expression of the PCE was higher than ACE (Student’s t test, *P < 0.05, ***P < 0.001). (B) Differences in calcineurin activity differences between the PCE and ACE at 0, 1, 2, and 3 dpa (Student’s t test, *P < 0.05, **P < 0.01, ***P < 0.001). Data are presented as mean ± SD. (C) PCE regeneration was induced by CsA treatment (n = 5/10) compared with DMSO treatment (n = 7/10). (D) Quantification of fin regenerative tissue lengths (in micrometers) of the PCE after FK506 or CsA treatment (n = 5). (E) Calcineurin activities of the PCE after FK506 or CsA treatment (n = 7, ***P < 0.001). P, proximal; D, distal. Data are presented as mean ± SD. (Scale bars: 500 µM.)

Expression Data

Gene:	ppp3ca
Fish:	WT
Condition:	amputation: caudal fin
Anatomical Term:	blastema distal side
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	amputation: caudal fin, chemical treatment by environment: cyclosporin A amputation: caudal fin
Observed In:	blastema distal side blastema proximal/distal pattern formation blastema regulation of calcineurin-mediated signaling caudal fin regulation of direction of cell growth regenerating fin polarity specification of proximal/distal axis
Stage:	Adult

Phenotype Detail

Acknowledgments

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