FIGURE

Fig. 4

ID

ZDB-FIG-210217-52

Publication

Begeman et al., 2020 - Decoding an Organ Regeneration Switch by Dissecting Cardiac Regeneration Enhancers

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Fig. 4

Evidence of the presence of a repressive element within a 22?bp cLEN sequence. (A) Transgene constructs examined for reporter gene expression. Endocardial expression results are summarized on the right. EC, endocardial cell. Uninj. and Reg. correspond to uninjured and 3?dpa regenerating hearts, respectively. (B) Images of sections of transgenic fish carrying cLEN deletion transgenes. Top, uninjured hearts. Middle, the remote zone of 3?dpa hearts. Bottom, the border zone of 3?dpa hearts. The arrows indicate endocardial EGFP expression. (C) Quantification of EGFP⁺ area per 100?�m2 cardiac tissue in uninjured hearts. (D) Quantification of EGFP⁺ area per 100?�m2 cardiac tissue in the border zone of 3?dpa hearts. (E) Quantification of EGFP⁺ area per 100?�m2 cardiac tissue in the remote zone of 3?dpa hearts. The data are presented as the mean�s.d. Numbers of animals are shown in Table S3. *P<0.05; **P<0.01; ***P<0.001; N.S., not significant. One-way ANOVA with Tukey's post-hoc test. Scale bar: 100?�m in B.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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