FIGURE

Fig. 6

ID

ZDB-FIG-210208-10

Publication

Reinoß et al., 2020 - Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits

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Fig. 6

Figure 6. Disruption of Mc4r Signaling in Zebrafish V2a Neurons Modulates Swimming Behavior (A) Schematic illustration of a dominant-negative Mc4r with a D90N amino acid exchange. (B) Alignment indicates that Mc4r D90N mutation is localized in a highly conserved region. (C and D) Swimming behavior of vsx2:Gal4FF; UAS:Mc4r(D90N) double-transgenic larvae and non-transgenic controls in absence of food (C) and with food (D) showed significant differences in swim bout frequencies (N = 8 animals; ∗p < 0.05, ∗∗p < 0.01; error bars show 95% confidence intervals). (E) Comparison of effects of V2a-specific dnMc4r / Mc4r(D90N) (N = 8) with the effects of the Mc4r antagonist SHU9119 (N = 12; see Figure S4), each relative to the corresponding controls.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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