FIGURE

Fig. 5

ID

ZDB-FIG-210205-22

Publication

Zhang et al., 2020 - Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signalling through Bmpr2a receptor

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Fig. 5

Analysis of the phenotype of the bmpr2b mutant. (A) Normal testicular growth and spermatogenesis in male bmpr2b mutant at 3 mpf. (B) Ovarian defects in female bmpr2b mutant at 3 and 5 mpf. Folliculogenesis was arrested at the MV stage in the bmpr2b mutant at both 3 and 5 mpf. (C) Follicle diameters measured on histological section. Two distant sections from each individual were chosen for quantification of PV and vitellogenic follicles with germinal vesicle visible, and three individuals of each genotype (#1-#3) were analyzed at 3 and 5 mpf. Data are mean±s.e.m. (D) Follicular atresia in the ovary of bmpr2b mutants showing abnormal chorion (arrows in bottom panels of d1 and d2) and hypertrophic granulosa cells (asterisks in bottom panel of d2). Staining with DAPI showed the hypertrophic granulosa cells (asterisks in d3) in comparison with normal follicles (d4). Bottom panels in d1 and d2 show higher magnification of the boxed areas above. SC, spermatocytes; SG, spermatogonia; ST, spermatids; SZ, spermatozoa. Arrows indicate ovaries or testes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmpr2b^umo26/umo26 (AB) bmpr2b^umo26/+ (AB)
Observed In:	granulosa cell ovarian follicle development ovarian follicle stage I ovary chorion testis testis spermatogenesis
Stage:	Adult

Phenotype Detail

Acknowledgments

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