FIGURE

FIGURE 1

ID

ZDB-FIG-210204-84

Publication

Wang et al., 2021 - The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Impairs the Vascular Development of Zebrafish Larvae

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FIGURE 1

Ibrutinib had potent toxicity in zebrafish embryos. (A) Ibrutinib induced a developmental deficiency in treated embryos at 72 h post-fertilization (hpf); a shorter body length, pericardial edema, and arrested blood flow were observed. Scale bar: 300 μm. (B) Heart rate of ibrutinib-treated embryos at 72 hpf; n = 10 for each group. (C) Survival curves of embryos treated with DMSO or ibrutinib at 12 hpf, survival rate was calculated from three independent experiments; n = 60 for each group in total. Asterisks indicate significant differences (DMSO vs. ibrutinib), **p < 0.01, ***p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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