FIGURE

Figure 4

ID

ZDB-FIG-210101-10

Publication

Spreafico et al., 2020 - The Genome-Wide Impact of Nipblb Loss-of-Function on Zebrafish Gene Expression

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Figure 4

(A) Dot plot of the top 15 significantly enriched (normalized enrichment score NES > 0 and FDR ≤ 0.05) and depleted (normalized enrichment score NES < 0 and FDR ≤ 0.05) gene sets from Gene Set Enrichment Analysis of nipblb-MO at 24 hpf as compared to their ctrl-MO counterpart. Dot color indicates statistical significance of the enrichment (false discovery rate FDR), dot size represents the fraction of genes annotated to each term. Gene sets are ranked in decreasing order based on the NES value. (B) Dot plot of the significantly enriched (normalized enrichment score NES > 0 and FDR ≤ 0.05) and depleted (normalized enrichment score NES < 0 and FDR ≤ 0.05) myeloid differentiation and AML-related gene sets from Gene Set Enrichment Analysis of nipblb-MO at 24 hpf as compared to their ctrl-MO counterpart. (C) Average expression in NMP1 mutant and wild-type AMLs of 3972 genes down-regulated by nipblb loss-of-function at 24 hpf (* p = 0.016 in unpaired t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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