FIGURE

Figure 8

ID

ZDB-FIG-201214-18

Publication

Chang et al., 2020 - Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

Other Figures

All Figure Page

Back to All Figure Page

Figure 8

TAN blocks PMA induced hypoxia-inducible factor 1-alpha (HIF-1α) and nuclear factor kappa-light-chain-enhancer of activated b cells (NF-κB) inflammatory crosstalk. (A) Concept building diagram representing the interaction and crosstalk between HIF-1α and NF-κB after PMA challenge on mice ears, (B) PKCα expression on mice ear tissues evaluated by immunohistochemical analysis, (C) NF-κB-p65 levels evaluated by immunohistochemical analysis, (D) HIF-1α evaluated by immunohistochemical analysis, (E) Western blotting analysis cytoplasmic HIF-1α and NF-κB pathway markers evaluated from ear tissue homogenates. Scale bar (100 μM). Magnification = 200×. Statistical significance analysis was carried out through a one-way analysis of variance (ANOVA) prism. * p < 0.05, ** p < 0.01, *** p < 0.001 and ns (non-significant).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.