Figure 6

Top (ex): Predicted structure of the extracellular domain plus transmembrane region of seven selected Robo proteins. Bottom (cp): Predicted structure of the transmembrane region plus cytoplasmic part of seven selected Robo proteins. Robo1 orthologues of two deuterostomes (Hsap = Homo sapiens; Spur = Strongylocentrotus purpuratus), one lophotrochozoan (Lana = Lingula anatina), two ecdysozoans (Dmel = Drosophila melanogaster; Tpse = Trichinella pseudospiralis), and two cnidarians (Hvul = Hydra vulgaris; Spis = Stylophora pistillata) were analysed. "% conf" indicates the percentage of residues modelled at >90% confidence. "% dis" indicates the predicted percentage of disordered regions. Bottom right: Schematic outline of the Robo domain structure with five immunoglobulin domains (IG1–IG5) and three fibronectin type III domains (FN3) in the extracellular part and four conserved cytoplasmic motifs (CC0–CC3) in the intracellular part. Like their bilaterian counterparts, cnidarian Robo candidates display a disorganised protein structure in the cytoplasmic part despite differences in structural features (Figure 6—figure supplement 1, Figure 6—figure supplement 2). The extracellular part (top row), on the other hand, is similarly organised across metazoans.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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