FIGURE

Figure 4 - figure supplement 1 - source data 1

ID

ZDB-FIG-200916-22

Publication

Ichino et al., 2020 - Building the vertebrate codex using the gene breaking protein trap library

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Figure 4 - figure supplement 1 - source data 1

Summary data analyzing the parameters of Ca<sup>2+</sup> transients in individual tested cells.
wt = ryr1b^+/+, gbt348hom = ryr1b^mn0348Gt^/mn0348Gt, peak = peak ∆F/F₀, and peaknum = number of transients/responses ≥ 0.05 ∆F/F₀.
Ca<sup>2+</sup> transients in <italic>ryr1b<sup>+/+</sup></italic> myocytes have higher peak amplitude and are more frequent than in <italic>ryr1b<sup>mn0348Gt</sup></italic><sup>/<italic>mn0348Gt</italic></sup> myocytes. (A) Dot plot comparing peak ∆F/F₀ responses (averaged within cell) between ryr1b^+/+ and ryr1b^mn0348Gt^/mn0348Gt animals. (B) Dot plot representing the number of responses per cell (≥0.05 ∆F/F₀) recorded during the 3 min imaging window in ryr1b^+/+ and ryr1b^mn0348Gt^/mn0348Gt animals. Plots show median with interquartile range. n_ryr1b+/+ = 64 cells, n_{ryr1bmn0348Gt}_/mn0348Gt = 48 cells. Data were compiled from four independent experiments containing at least two animals in each group. p-values determined using the Mann-Whitney U test. Effect size (Cohen’s d)=1.445 (A) and 0.931 (B). Source data can be found in Figure 4—figure supplement 1—source data 1. Figure 4—figure supplement 1—source data 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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