FIGURE

Fig. 1.

ID

ZDB-FIG-200910-18

Publication

Oppel et al., 2020 - suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma

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Fig. 1.

Loss of suz12 in p53/nf1-deficient fish diversifies carcinogenesis. (A) CRISPR-Cas9-mediated targeting truncates Suz12a and Suz12b proteins before their functional domains, conferring a loss of function. VEFS, VRN2-EMF2-FIS2-SUZ12 domain; WDB, WD-40 binding domain; Zn, Zn-finger region. (B) p53/nf1/suz12-deficient fish are prone to tumors in various anatomical locations, e.g. the abdomen or head (arrows). (C) Histopathology analysis reveals a variety of cancer types in p53/nf1/suz12-deficient tumor-bearing fish, whereas p53/nf1-deficient control fish solely develop MPNSTs. Numbers underneath representative images indicate the frequency of the respective tumor type in nf1a^+/− or nf1^+/+ tumor-bearing fish analyzed by histology. Scale bars: 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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