FIGURE

FIGURE 2

ID

ZDB-FIG-200829-54

Publication

Liu et al., 2020 - Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan

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FIGURE 2

Morphological defects in the miR-430-deficient embryos. (A–O) The morphology of WT and miR-430-deficient embryos. The phenotypes are fully penetrant. Formation of the germ ring (black arrows) and shield (white arrows) were delayed in the miR-430^–/– mutants (A,B,F,G). The yolk was not enclosed by epiboly in the mutant at 9 hpf (C,H). The extension of the anterior-posterior body axis was reduced in the miR-430 mutants (D,E,I,J). The miR-430 mutants had no brain vesicles and lacked heart tissue and circulation (K,M). Tail blisters were observed in the mutant at 48 hpf (L,N). The miR-430 mimics but not the mismatched miR-430 with 2-nucleotide alterations could rescue the defects observed in the miR-430 mutants (O,P). The ratios of observed phenotypes were indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	Df(Chr4:mir430)zf3188/zf3188
Observed In:	blood circulation brain embryo development heart contraction heart development post-vent region shield ventricular system whole organism whole organism anterior-posterior axis yolk
Stage Range:	Germ-ring to Long-pec

Phenotype Detail

Acknowledgments

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