FIGURE

Fig. 7

ID

ZDB-FIG-200819-14

Publication

Gerrard et al., 2020 - Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

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Fig. 7

Neurodevelopmental de novo mutation within brain-specific histone modification correlated to surrounding gene expression.

An intergenic G-to-T de novo mutation (DNM; hg38, chr16:72427838) is shown for a patient with a neurodevelopmental phenotype. Tracks are shown demonstrating additional human embryonic non-coding transcription (enriched in human embryonic brain), the three epigenomic marks, ENCODE data²⁶ and conservation amongst vertebrates. The DNM overlaps a brain-specific (dark blue) H3K27ac and small H3K4me3 mark. The highest correlations are shown, notably to the promotors of ZNF821 (r = 0.92) (dark blue) with anticorrelation (r = −0.65, red) to the adjacent gene, ATXN1L.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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