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ZDB-FIG-200812-13

Publication

Davis et al., 2020 - Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity

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Fig. 1

Chloroquine causes dose-dependent hair cell loss in the zebrafish lateral line system. Fluorescent imaging showed robust hair cell numbers in control neuromasts (A) and reduced numbers in fish exposed to 400 μM chloroquine for 24 h (B). Hair cell counts show a decrease in hair cell viability as chloroquine concentration increased (F = 12.28, p < 0.0001; C). However, there was no significant change with concentrations from 400 μM to 1600 μM (p > 0.05). (D) This pattern was consistent between 24- and 1- hour exposure times with no statistical significance (F = 3.06, p = 0.0828). Error bars represent ±1 standard deviation. Scale bar = 10 μm.

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Reprinted from Hearing Research, 395, Davis, S.N., Wu, P., Camci, E.D., Simon, J.A., Rubel, E.W., Raible, D.W., Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity, 108019, Copyright (2020) with permission from Elsevier. Full text @ Hear. Res.