FIGURE

Fig 10

ID

ZDB-FIG-200718-37

Publication

Deveau et al., 2020 - Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

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Fig 10

Spectral plots and cone contribution comparisons for <italic>6BP+1</italic> and <italic>3BP</italic> larva.

(A) Scanning from 330 nm to 650 nm with constant quantal irradiance (4.6 log(quanta∙μm⁻²∙s⁻¹) the 6BP+1 mutant (N = 12) shows a large drop in response amplitude for long wavelengths and a strong preference for UV wavelengths compared to the wild type (N = 17) and heterozygote (N = 16). (B) The 3BP spectral plot shows a similar spectral pattern in response amplitude across the wavelengths between all genotypes. (C) The 6BP+1 mutant displays a significant drop in red cone contribution (Vr) accompanied by an increase in UV cone contribution (Vu). (D) The cone contribution comparisons between the 3BP genotypes show a trend towards decreasing Vr for the mutant and heterozygote as compared to wild type, though not significant. Spectral curves and fractional cone amplitudes in A-D are generated from the same datasets and model as in Fig 9.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	thrb^nds2/nds2 thrb^nds3/nds3 thrb^nds2/+ thrb^nds3/+
Observed In:	retinal cone cell cellular response to UV retinal cone cell response to red light
Stage:	Day 5

Phenotype Detail

Acknowledgments

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