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Fig. 8

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ZDB-FIG-200622-8
Publication
Hecker et al., 2020 - High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish
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Fig. 8

Evidence for additional slower processes that are not completed during axonal regrowth and recovery of latency.

a Linear regression between median angular speed (i.e., bending angle divided by bending duration) and axon length 1 day before escapes were recorded. While escape latency had been completely restored to preinjury levels when axons had regenerated to the state marked as ‘long axon’, median angular speed of the escapes stayed constant, i.e., the slope of the regression line does not differ from zero (P = 0.88; n = 68 stages in N = 16 larvae). b Boxplots show angular speed before injury and when the axons had regrown to short (<1200 μm) or long axon length (>1900 μm). Circles show medians of angular speed for each axon length. Note absence of significant differences (highlighted with different letters; Kruskal–Wallis with Dunn’s multiple comparison post-hoc test) in angular speed of the different states during axon regrowth and difference at both stages from the angular speed level seen before injury (P < 0.0001). Data were obtained from the same escape responses (and same regeneration states) as in Fig. 7 that showed complete restoration of escape latency.

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