FIGURE

Fig. 4

ID

ZDB-FIG-200518-10

Publication

McClean et al., 2020 - Early cell-autonomous accumulation of neutral lipids during infection promotes mycobacterial growth

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Fig. 4

Mutations at the mce4 locus eliminate the effect of ezetimibe on infection burden. a. Schematic representation of mce4 locus showing location of transposon insertion mutants. b. Comparison of infection burden at 12hpi, 3dpi, and 6dpi in animals infected with wild-type, yrbe4aTn22523, or yrbe4bTn5819 and then treated with vehicle alone (DMSO) or 1 μM ezetimibe. Student’s t-test *p = 0.021. Representative of three independent experiments. c. Median animals from 6dpi comparison groups in (b). Bar = 500μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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