FIGURE

Fig. 3.

ID

ZDB-FIG-200509-26

Publication

de Oliveira et al., 2020 - DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma

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Fig. 3.

Overexpression ofzfDnaJa-Pkacamodulates liver morphology. (A) Representative MIPs of 7 dpf FLC larvae [Tg(fabp10a:dnajb1a-prkacaa)/Tg(fabp10a:egfp-l10a)] and control siblings [Tg(fabp10a:egfp-l10a)]. Dotted red lines indicate liver area. (B,C) Graphs showing liver area (B) (control N=45, FLC N=53) and liver volume (C) (control N=22, FLC N=21). (D) Representative MIPs of 7 dpf FLC larvae [Tg(fabp10a:dnajb1a-prkacaa)/Tg(fabp10a:mCherry-kras)] and control siblings [Tg(fabp10a:mCherry-kras)]. Dashed red lines indicate hepatocyte area. (E-H) Graphs showing hepatocyte area (E,F) and diameter (G,H). In E and G, each dot represents one hepatocyte (control N=201, FLC N=261); in F and H, each dot represents one larva (control N=10, FLC N=13). Scale bars: 20 μm. Data are from at least three independent experiments. Analysis performed in EMM in R. Dot plots show mean±s.e.m.; P-values are shown on graphs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uwm45Tg; uwm47Tg mitfa^w2; mpv17^a9; uwm45Tg; uwm46Tg
Observed In:	hepatocyte liver
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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