FIGURE

Fig. 2.

ID

ZDB-FIG-200509-25

Publication

de Oliveira et al., 2020 - DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma

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Fig. 2.

Overexpression of Dnajb1a-Prkacaa(zfDnaJa-Pkaca)can induce liver masses at adult stages. (A) Representative maximum-intensity projections (MIPs) of 7 day post-fertilization (dpf) FLC larvae [Tg(fabp10a:dnajb1a-prkacaa)/Tg(fabp10a:egfp-l10a)] and control siblings [Tg(fabp10a:egfp-l10a)]. (B) Chi-square graphs showing percentages of fish with masses (8 months, control N=5, FLC N=8; 12 months, control N=5, FLC N=7). (C) Representative images of H&E staining of the livers of 12-month-old fish at 10× and 40× magnification. Yellow outlines delineate masses, white arrowheads indicate prominent nucleoli and black arrowheads indicate lipid vacuoles. Scale bars: 60 μm (10× magnification) and 10 μm (40× magnification). M, mass; N, normal tissue.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2; mpv17^a9; uwm45Tg; uwm46Tg
Observed In:	hepatocyte nucleolus liver liver carcinoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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