FIGURE

Figure 4

ID

ZDB-FIG-200502-7

Publication

Hanh et al., 2020 - Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Evaluation of in vivo RFM O activity on M. abscessus CIP 104536 R morphotype expressing mWasabi infection. Zebrafish (ZF) were infected with M. abscessus CIP 104536^T R expressing mWasabi, and treated with different antibiotics. The M. abscessus infected ZF were exposed to RIF, RFT, RFM O, RFB and CLR at a concentration of 25 μM and compared to untreated controls. Green fluorescent protein (GFP) dissemination in ZF was captured using fluorescent microscopy (A). The 5 dpi embryos at 25 µM of RIF, RFT, RFM O, RFB and CLR show significant reductions in infection burden (*** P < 0.0001; ns, not significant) (B). Survival of M. abscessus-infected embryos treated at 25 μM of rifamycin analogs and clarithromycin (C) in comparison with untreated infected embryos and non-treated control (n = 20, representative of three independent experiments). * P < 0.05, *** P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Molecules