FIGURE

Figure 5

ID

ZDB-FIG-200421-30

Publication

S Alqahtani et al., 2020 - Cytotoxic Evaluation and Anti-Angiogenic Effects of Two Furano-Sesquiterpenoids from Commiphora myrrh Resin

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Figure 5

2-methoxyfuranodiene inhibited the secondary angiogenic blood vessel formation in zebrafish embryos. (A) Bright field image of a Tg(fli1:EGFP) embryo that was exposed to 0.1% methanol as a control. The embryos developed normally. (B) The fluorescent image of a Tg (fli1: EGFP) embryo at 72 hpf. The green color indicates all the blood vessels. The white arrows show the inter-segmental blood vessels in the trunk of the mock-treated zebrafish embryo, which were the first angiogenic blood vessels that formed at around 48 hpf. The emergence of the second angiogenic blood vessels can be seen on the trunk of the control embryo. (C) The bright field image of a Tg (fli1: EGFP) embryo treated with 10 µM of CM1. The bright field image shows the normal development of the embryos. (D) The fluoresce image of a Tg (fli1: EGFP) zebrafish embryo treated with 15 µM of CM1 showed the normal formation of the inter-segmental blood vessels. However, the treated embryos do not have the sub-intestinal vein blood vessels (indicated by white asterisks).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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