FIGURE

Fig. 2

ID

ZDB-FIG-200416-1

Publication

Wu et al., 2020 - Disruption of dmrt1 rescues the all-male phenotype of cyp19a1a mutant in zebrafish - A Novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis

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Fig. 2

Phenotype analysis of female zebrafish in different genotypes. (A,B) Histological examination of gonads in different genotypes of dmrt1;cyp19a1a at 75?dpf (A) and 100?dpf (B). PG, primary growth; PV, pre-vitellogenic; EV, early vitellogenic; FG, full grown. Arrows indicate atresic/degenerating follicles. Asterisks indicate stromal cells. (C,D) Ratios of PG, PV and vitellogenic (EV+) follicle areas in different genotypes at 75?dpf (C) and 100?dpf (D). Data are mean�s.d. The exact values are shown under the x-axis. (E) The size of PV follicles in controls and double mutants (dmrt1?/?;cyp19a1a?/?) at 100?dpf. Each dot represents the average diameter of PV follicles with visible germinal vesicles from each fish (quantified from three different sections). Data are mean�s.d. and the exact values are shown under the x-axis. Statistical significance was revealed by two-tailed unpaired Student's t-test (**P<0.01).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cyp19a1a^umo5/umo5; dmrt1^umo15/umo15 (AB)
Observed In:	ovarian follicle stage II ovarian follicle stage III ovarian follicle stage IV
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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