FIGURE

Figure 6

ID

ZDB-FIG-200406-54

Publication

Guo et al., 2020 - A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity

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Figure 6

Effect of mutant KIF1A on excitatory synapses. (A) Representative image of dendritic spines at DIV16 from neurons transfected with the mutant or wild-type KIF1A plasmid. (B) Total spines/10 μm of neurons expressing the mutant (n = 26 neurons) or wild-type protein (n = 23 neurons). (***p < 0.001, Student's t test). (C) Representative image of vGLUT at DIV16 from neurons transfected with the mutant or wild-type KIF1A plasmid. (D) Total vGLUT/10 μm of neurons expressing the mutant (n = 24 neurons) or wild-type protein (n = 21 neurons). (**p < 0.01, Student's t test). (E) Representative image of excitatory synapses (vGLUT-positive PSD-95 clusters) at DIV16 from neurons transfected with the mutant or wild-type KIF1A plasmid. (F) Total excitatory synapses (vGLUT-positive PSD-95 clusters)/10 μm of neurons expressing the mutant (n = 19 neurons) or wild-type protein (n = 18 neurons). (*p < 0.05, Student's t test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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