FIGURE

Figure 8

ID

ZDB-FIG-200325-160

Publication

Bae et al., 2020 - Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis

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Figure 8

Anti-angiogenic activity of fucoidan in vivo and in vitro. (A) Zebrafish fli1 Tg (eGFP) models were analyzed to visualize vascular development in response to fucoidan. Fucoidan disrupted vasculature development, especially dorsal longitudinal anastomotic vessel (DLAV), dorsal aorta (DA), and intersegmental vessels (ISVs). Scale bar indicates 300 μm in left panels and 60 μm in right magnified panels. (B–G) Expression of angiogenesis-related genes was validated in fucoidan-treated fli1 Tg zebrafish by quantitative RT-PCR analysis. (H–N) Reduction of angiogenesis-related genes in ES-2 and OV-90 cells with the combination of fucoidan and cisplatin or paclitaxel. Messenger RNA expression of target genes was calculated based on that of GAPDH gene. *** p < 0.001, ** p < 0.01, and * p < 0.05 indicate significant effects of each treatment compared with vehicle-treated control cells. # represents significances (p < 0.05) compared with fucoidan alone.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Condition:	chemical treatment by environment: fucoidan
Observed In:	dorsal aorta dorsal longitudinal anastomotic vessel intersegmental vessel vasculature development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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