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ZDB-FIG-200319-38

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Lanni et al., 2019 - Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development

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Fig. 3

Schleier is caused by mutation of slc12a7a encoding potassium chloride cotransporter Kcc4a. A) Multispecies alignment of predicted coding sequence of slc12a7a showing position of altered residue in Kcc4a in the schleier mutant. Schematic representation redrawn after (Marcoux et al., 2017). B) Adult wildtype P0 zebrafish with somatic clones harboring deletions of slc12a7a/kcc4a. Arrow points to tip of barbel; bracket shows extent of growth. C) Close up of anal fin labeled in (B) showing elongated segments of the rays (joints marked *); normal segmentation pattern observed just above (arrowheads). D) Sequence of deletions identified in affected region of anal fin and frequency (12/16); blue box, sequence of the guide RNA used in targeting.

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Reprinted from Developmental Biology, 456(2), Lanni, J.S., Peal, D., Ekstrom, L., Chen, H., Stanclift, C., Bowen, M.E., Mercado, A., Gamba, G., Kahle, K.T., Harris, M.P., Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development, 164-178, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.