FIGURE

Fig. 6.

ID

ZDB-FIG-200314-86

Publication

Bryan et al., 2020 - Optic cup morphogenesis requires neural crest-mediated basement membrane assembly

Other Figures

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Fig. 6.

Nid1a overexpression partially rescues optic cup morphogenesis in tfap2a;foxd3 mutants. (A-D′) Double-transgenic embryos [Tg(bactin2:EGFP-CAAX);Tg(hs:WT-Nid1a)]: sibling control and tfap2a;foxd3 mutant embryos not heat shocked (A-B′), or heat shocked at 12-13 hpf (C-D′). Dorsal view, single confocal sections, 24 hpf. (E-G) Quantification of invagination angle (E), optic fissure angle (F) and lens roundness (G). n (embryos) shown in the base of the graph, from two or three experiments. P-values were calculated using one-way ANOVA with Tukey HSD post-hoc test. Scale bar: 50 μm. L, lateral; M, medial; N, nasal; T, temporal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	z200Tg; z202Tg tfap2a^ts213/ts213; foxd3^zdf10/zdf10; z200Tg tfap2a^ts213/ts213; foxd3^zdf10/zdf10; z200Tg; z202Tg
Condition:	heat shock
Observed In:	closure of optic fissure lens optic cup morphogenesis involved in camera-type eye development
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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