FIGURE

Fig. 6

ID

ZDB-FIG-200207-6

Publication

Tian et al., 2020 - Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration

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Fig. 6

Schwann cells are not essential for the maintenance of Sarm1-deficient sensory axons.

a–c Images of mCherry-expressing (red) transected axons in wild type (a), Erbb2−/− mutants (b), and Sarm1−/−; ErBb2−/− double mutants (c). Scale bar 100 μm. d Quantification of transected axon fragmentation in Erbb2−/− and Sarm1−/−; ErBb2−/−. Error bar = SEM, p value from one-way ANOVA test, n = 15 (each group). e Image of from Supplementary Movie 1, showing the discrete local defasciculation of regenerated the sensory fiber (red) and the bridging of the glial gap by Schwann cells (green) in a wild-type specimen. f Equivalent experiment, taken from Supplementary Movie 2, showing a more pronounced local defasciculation of the regenerated the sensory fiber (red) in a Sarm1-mutant specimen. Note that the bridging of the glial gap does not occur.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	erbb2^{nksagff202aTg}; bc3Tg; nkuasgfp1aTg erbb2^st61/st61; erbb2^{nksagff202aTg}; bc3Tg; nkuasgfp1aTg erbb2^{nksagff202aTg}; sarm1^hzm13/hzm13; bc3Tg; nkuasgfp1aTg erbb2^st61/st61; erbb2^{nksagff202aTg}; sarm1^hzm13/hzm13; bc3Tg; nkuasgfp1aTg
Condition:	transection: axon: posterior lateral line nerve
Observed In:	lateral line nerve axon lateral line nerve regenerating tissue
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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