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Fig. 6

ID: ZDB-IMAGE-200207-6
Publication: Tian et al., 2020 - Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration
All Figures: Figures for Tian et al., 2020

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Figure Caption

Fig. 6 Schwann cells are not essential for the maintenance of Sarm1-deficient sensory axons.

a–c Images of mCherry-expressing (red) transected axons in wild type (a), Erbb2−/− mutants (b), and Sarm1−/−; ErBb2−/− double mutants (c). Scale bar 100 μm. d Quantification of transected axon fragmentation in Erbb2−/− and Sarm1−/−; ErBb2−/−. Error bar = SEM, p value from one-way ANOVA test, n = 15 (each group). e Image of from Supplementary Movie 1, showing the discrete local defasciculation of regenerated the sensory fiber (red) and the bridging of the glial gap by Schwann cells (green) in a wild-type specimen. f Equivalent experiment, taken from Supplementary Movie 2, showing a more pronounced local defasciculation of the regenerated the sensory fiber (red) in a Sarm1-mutant specimen. Note that the bridging of the glial gap does not occur.

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