FIGURE

Figure 5

ID

ZDB-FIG-200127-12

Publication

Afonin et al., 2020 - Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

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Figure 5

Phototherapeutic cytotoxic action against HeLa cells of GS 1 and its photoswitchable analogues 2–20, correlated with the new in vivo results and earlier in vitro data. For each peptide, the HeLa cytotoxic concentrations of the ring-open photoforms (IC₅₀(open)) are plotted against the corresponding in vivo toxicities to D. rerio embryos (A, LD₅₀(closed)^24h), or against the in vitro hemolytic activities (B, HC₅₀(closed), i.e., 50% hemolysis]) of the ring-closed photoforms. The compound numbers are shown next to the data points. The in vitro data is from [30]. Values for the parent peptide 1 are marked black, and a white filling highlights the initial prototype 2. Color codes for the remaining peptides are the same as in Fig. 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Beilstein J Org Chem