Figure 5

Figure 5

Phototherapeutic cytotoxic action against HeLa cells of GS 1 and its photoswitchable analogues 2–20, correlated with the new in vivo results and earlier in vitro data. For each peptide, the HeLa cytotoxic concentrations of the ring-open photoforms (IC₅₀(open)) are plotted against the corresponding in vivo toxicities to D. rerio embryos (A, LD₅₀(closed)^24h), or against the in vitro hemolytic activities (B, HC₅₀(closed), i.e., 50% hemolysis]) of the ring-closed photoforms. The compound numbers are shown next to the data points. The in vitro data is from [30]. Values for the parent peptide 1 are marked black, and a white filling highlights the initial prototype 2. Color codes for the remaining peptides are the same as in Fig. 3.