FIGURE

Fig. 4

ID
ZDB-FIG-200124-55
Publication
Toms et al., 2019 - Missense variants in the conserved transmembrane M2 protein domain of KCNJ13 associated with retinovascular changes in humans and zebrafish
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Fig. 4

Retinal vasculature in obetd15 zebrafish.

OCT en face images of the dorsal retina show inner retinal vessels emerging from the optic nerve region in the wild-type (a) and obetd15 (b) fish at 12 months post-fertilization, displaying abnormal blood vessel appearance in the mutant retina. Cross-sectional B-scans from wild-type (c) and obetd15 (d) fish also demonstrate notable differences in vessel size (vessels indicated with *). Numbered brackets (1–4) on the cross-sections represent areas analyzed in the corresponding en face images. Fibrous material was apparent at each depth examined in the vitreous of the obetd15 retina (3, 4) but was not seen on the wild-type images (1, 2). Hyper-reflective deposits were also noted in the vitreous of the obetd15 retina on both B-scan (e) and en face (f) images, indicated with arrows. Graph (g) shows retinal vessel thickness plotted against distance from the optic nerve in wild-type and obetd15 zebrafish. Scale bars = 50 μm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
Acknowledgments
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Reprinted from Experimental Eye Research, 189, Toms, M., Dubis, A.M., Lim, W.S., Webster, A.R., Gorin, M.B., Moosajee, M., Missense variants in the conserved transmembrane M2 protein domain of KCNJ13 associated with retinovascular changes in humans and zebrafish, 107852, Copyright (2019) with permission from Elsevier. Full text @ Exp. Eye. Res.