FIGURE

Figure 2.

ID

ZDB-FIG-191230-208

Publication

Swidergall et al., 2019 - Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection

Other Figures

All Figure Page

Back to All Figure Page

Figure 2.

Systemic infection of zebrafish larvae with ECE1-deficient Candida albicans show improved survival compared with wild-type or ece1Δ/Δ+ECE1-infected zebrafish. (A) Zebrafish survival 24 hours after injection of 500 colony-forming unit of wild-type, ece1Δ/Δ, ece1Δ/Δ+ECE1, als3Δ/Δ or phosphate-buffered saline (PBS) as control directly into the cardinal vein. Data are presented as mean ± standard deviation (n = 4 independent experiments with at least 20 zebrafish per treatment group); statistical analysis was achieved using one-way analysis of variance with Tukey’s post hoc multiple comparison test. **, P < .01; and ***, P < .001. (B) Sagittal histological sections of periodic acid-Schiff-stained infected zebrafish showing the hyphal form of C albicans penetrating zebrafish tissue for wild-type, ece1Δ/Δ and ece1Δ/Δ+ECE1 strains compared with PBS-injected controls. Scale bars = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	fungal treatment by injection: Candida albicans
Observed In:	whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Infect. Dis.