FIGURE

FIGURE 3

ID

ZDB-FIG-191230-1117

Publication

Wang et al., 2019 - Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 3

wipi1 mRNA variants affected the convergent extension in zebrafish embryos treated with wipi1-MO. (A)WIPI1 WT mRNA of 100–300 pg rescued the convergent extension defects induced by co-injection of wipi1-MO in zebrafish embryos at 24 and 48 hpf. There was no difference in malformation between embryos co-treated with 100 pg mRNA and wipi1-MO dosage and control embryos untreated with MO or mRNA. (B)WIPI1 mRNA co-injected with wipi1-MO rescued the convergent extension. However, WIPI1 R328Q, G313R, T418M, or L406P mRNA injection failed to rescue the phenotype, while WIPI1 WT mRNA injection compensated for the phenotype (^∗P < 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.