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FIGURE 3

ID: ZDB-IMAGE-191230-1128
Publication: Wang et al., 2019 - Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases
All Figures: Figures for Wang et al., 2019

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Figure Caption

FIGURE 3

wipi1 mRNA variants affected the convergent extension in zebrafish embryos treated with wipi1-MO. (A)WIPI1 WT mRNA of 100–300 pg rescued the convergent extension defects induced by co-injection of wipi1-MO in zebrafish embryos at 24 and 48 hpf. There was no difference in malformation between embryos co-treated with 100 pg mRNA and wipi1-MO dosage and control embryos untreated with MO or mRNA. (B)WIPI1 mRNA co-injected with wipi1-MO rescued the convergent extension. However, WIPI1 R328Q, G313R, T418M, or L406P mRNA injection failed to rescue the phenotype, while WIPI1 WT mRNA injection compensated for the phenotype (^∗P < 0.05).

Acknowledgments

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