ZFIN ID: ZDB-FIG-191114-6
Punwani et al., 2016 - Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B. The New England Journal of Medicine   375:2165-2176 Full text @ N. Engl. J. Med.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Prim-25 to Day 5
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-25 to Day 5

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
ccr9b WT + MO1-bcl11ba standard conditions Prim-25 whole organism RTPCR
Day 5 whole organism RTPCR
EGFP la2Tg standard conditions Protruding-mouth thymus thrombocyte IFL
la2Tg + MO1-bcl11ba standard conditions Protruding-mouth Not Detected thymus thrombocyte IFL
la2Tg + MO1-bcl11ba + MO1-ccr9b standard conditions Protruding-mouth thymus thrombocyte IFL
la2Tg + MO1-ccr9b standard conditions Protruding-mouth thymus thrombocyte IFL
myb WT control Prim-25 hematopoietic cell ISH
WT + MO1-bcl11ba standard conditions Prim-25 hematopoietic cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-bcl11ba standard conditions Prim-25 hematopoietic cell myb expression increased distribution, abnormal
Prim-25 hematopoietic stem cell migration decreased occurrence, abnormal
Prim-25 whole organism ccr9b expression increased amount, abnormal
Day 5 whole organism ccr9b expression increased amount, abnormal
la2Tg + MO1-bcl11ba standard conditions Protruding-mouth lymphoid lineage cell migration into thymus decreased occurrence, abnormal
Protruding-mouth thymus thrombocyte EGFP expression absent, abnormal
la2Tg + MO1-bcl11ba + MO1-ccr9b standard conditions Protruding-mouth lymphoid lineage cell migration into thymus occurrence, ameliorated
Protruding-mouth thymus thrombocyte EGFP expression amount, ameliorated
Full text @ N. Engl. J. Med.