FIGURE

Fig. 1

ID

ZDB-FIG-190913-68

Publication

Leerberg et al., 2019 - Fibroblast Growth Factor Receptors Function Redundantly During Zebrafish Embryonic Development

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Fig. 1

Fgf receptor mutants are embryonic viable. (A) Schematic diagram of a typical full-length Fgfr protein and the predicted truncated peptides resulting from the fgfr1a^uc61, fgfr1b^uc62, fgfr2^uc64, fgfr3^uc51, and fgfr4^uc42 alleles. Hatching indicates missense amino acids. (B) RT-PCR of wild-type embryos. While all fgfr isoforms are detected in 24 hr postfertilization (hpf) embryos (postzygotic genome activation, bottom panel), only fgfr1a (isoform IIIc) and fgfr1b are detected in 1.5 hpf embryos (prezygotic genome activation, top panel). ef1a is shown as a positive control. (C–H) Lateral view of ∼28 hpf wild-type (WT, C) or homozygous mutant (D–H) embryos. Anterior is to the left, dorsal is up. Bar in (H), 200 μm for (C–H). Ig, immunoglobulin; LB, ligand-binding domain; SP, signal peptide; TM, transmembrane domain.

Expression Data

Genes:	fgfr1a fgfr1b fgfr2 fgfr3 fgfr4
Fish:	WT
Anatomical Term:	whole organism
Stage Range:	16-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgfr1a^uc61/uc61 fgfr1b^uc62/uc62 fgfr2^uc64/uc64 fgfr3^uc51/uc51 fgfr4^uc42/uc42
Observed In:	whole organism
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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