Gene

fgfr1b

ID

ZDB-GENE-060503-14

Name

fibroblast growth factor receptor 1b

Symbol

fgfr1b Nomenclature History

Previous Names

si:ch211-180b9.1

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including fibroblast growth factor receptor signaling pathway; pectoral fin development; and post-anal tail morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Is expressed in several structures, including basal plate midbrain region; forebrain neural keel; forebrain neural rod; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cssl:d811 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Leerberg et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgfr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 2 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 2 with or without anosmia	147950
Jackson-Weiss syndrome	Alliance	Jackson-Weiss syndrome	123150
osteoglophonic dysplasia	Alliance	Osteoglophonic dysplasia	166250
Pfeiffer syndrome	Alliance	Pfeiffer syndrome	101600
		Encephalocraniocutaneous lipomatosis, somatic mosaic	613001
		Hartsfield syndrome	615465
		Trigonocephaly 1	190440

Associated With fgfr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Length
UniProtKB:A0A8M9QKR2 InterPro	510
UniProtKB:A0A8M2BGG7 InterPro	738
UniProtKB:A0A8M9QC50 InterPro	740
UniProtKB:A0A8M1NUM7 InterPro	740
UniProtKB:A0A8M3B3N4 InterPro	731