Gene

fgfr1b

ID

ZDB-GENE-060503-14

Name

fibroblast growth factor receptor 1b

Symbol

fgfr1b Nomenclature History

Previous Names

si:ch211-180b9.1

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including fibroblast growth factor receptor signaling pathway; pectoral fin development; and post-anal tail morphogenesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including basal plate midbrain region; forebrain neural keel; forebrain neural rod; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

22 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d811 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Leerberg et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgfr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 2 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 2 with or without anosmia	147950
Jackson-Weiss syndrome	Alliance	Jackson-Weiss syndrome	123150
osteoglophonic dysplasia	Alliance	Osteoglophonic dysplasia	166250
Pfeiffer syndrome	Alliance	Pfeiffer syndrome	101600
		Encephalocraniocutaneous lipomatosis, somatic mosaic	613001
		Hartsfield syndrome	615465
		Trigonocephaly 1	190440

Associated With fgfr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR016248	Fibroblast growth factor receptor family
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9QKR2	InterPro	510
UniProtKB:A0A8M2BGG7	InterPro	738
UniProtKB:A0A8M9QC50	InterPro	740
UniProtKB:A0A8M1NUM7	InterPro	740
UniProtKB:A0A8M3B3N4	InterPro	731

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fgfr1b-201 (1) Ensembl	Ensembl	2,736 nt	Select Tool ZFIN BLAST
mRNA	fgfr1b-202 (1) Ensembl	Ensembl	2,814 nt	Select Tool ZFIN BLAST
mRNA	fgfr1b-203 (1) Ensembl	Ensembl	1,038 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations