Gene
fgfr1b
- ID
- ZDB-GENE-060503-14
- Name
- fibroblast growth factor receptor 1b
- Symbol
- fgfr1b Nomenclature History
- Previous Names
-
- si:ch211-180b9.1
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including fibroblast growth factor receptor signaling pathway; pectoral fin development; and post-anal tail morphogenesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including basal plate midbrain region; fin; forebrain neural keel; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d811 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Leerberg et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017590Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13288 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14213 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uc62 | Allele with one deletion | Exon 6 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgfr1b | Leerberg et al., 2019 | |
| CRISPR2-fgfr1b | Chen et al., 2020 | |
| CRISPR3-fgfr1b | Chen et al., 2020 | |
| MO1-fgfr1b | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 2 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 2 with or without anosmia | 147950 |
| Jackson-Weiss syndrome | Alliance | Jackson-Weiss syndrome | 123150 |
| osteoglophonic dysplasia | Alliance | Osteoglophonic dysplasia | 166250 |
| Pfeiffer syndrome | Alliance | Pfeiffer syndrome | 101600 |
| Encephalocraniocutaneous lipomatosis, somatic mosaic | 613001 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibroblast growth factor receptor family | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QKR2 | InterPro | 510 | ||||||||||||||
| UniProtKB:A0A8M2BGG7 | InterPro | 738 | ||||||||||||||
| UniProtKB:A0A8M9QC50 | InterPro | 740 | ||||||||||||||
| UniProtKB:A0A8M1NUM7 | InterPro | 740 | ||||||||||||||
| UniProtKB:A0A8M3B3N4 | InterPro | 731 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fgfr1b-201
(1)
|
Ensembl | 2,736 nt | ||
| mRNA |
fgfr1b-202
(1)
|
Ensembl | 2,814 nt | ||
| mRNA |
fgfr1b-203
(1)
|
Ensembl | 1,038 nt |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-180B9 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d811 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161732 (1) | 2420 nt | ||
| Genomic | GenBank:AL935178 (1) | 144027 nt | ||
| Polypeptide | UniProtKB:A0A8M1NUM7 (1) | 740 aa |
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Gebuijs, L., Wagener, F.A., Zethof, J., Carels, C.E., Von den Hoff, J.W., Metz, J.R. (2022) Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae. PeerJ. 10:e14338e14338
- Rayrikar, A.Y., Wagh, G.A., Santra, M., Patra, C. (2022) Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development (Cambridge, England). 150(1):
- Klingbeil, K., Nguyen, T., Fahrner, A., Guthmann, C., Wang, H., Schoels, M., Lilienkamp, M., Franz, H., Eckert, P., Walz, G., Yakulov, T.A. (2021) Corpuscles of Stannius development requires FGF signaling. Developmental Biology. 481:160-171
- Chang, C.T., Lee, Y.H., HuangFu, W.C., Liu, I.H. (2020) Cell-intrinsic Fgf signaling contributes to primordial germ cell homing in zebrafish. Theriogenology. 158:424-431
- Chen, J., Poskanzer, K.E., Freeman, M.R., Monk, K.R. (2020) Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. 23(10):1297-1306
- Li, Y.Q., Chen, Y., Fang, J.Y., Jiang, S.Q., Li, P., Li, F. (2020) Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease. Journal of ethnopharmacology. 254:112764
- Leerberg, D.M., Hopton, R.E., Draper, B.W. (2019) Fibroblast Growth Factor Receptors Function Redundantly During Zebrafish Embryonic Development. Genetics. 212(4):1301-1319
- Lush, M.E., Diaz, D.C., Koenecke, N., Baek, S., Boldt, H., St Peter, M.K., Gaitan-Escudero, T., Romero-Carvajal, A., Busch-Nentwich, E.M., Perera, A.G., Hall, K.E., Peak, A., Haug, J.S., Piotrowski, T. (2019) scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. eLIFE. 8:
- Chiquet, B.T., Yuan, Q., Swindell, E.C., Maili, L., Plant, R., Dyke, J., Boyer, R., Teichgraeber, J.F., Greives, M.R., Mulliken, J.B., Letra, A., Blanton, S.H., Hecht, J.T. (2018) Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes. European journal of human genetics : EJHG. 26(10):1441-1450
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