FIGURE

Fig. 6

ID

ZDB-FIG-190815-51

Publication

Sundqvist et al., 2018 - JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion

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Fig. 6

WNT7B promotes breast cancer cell invasion. (A) MCF10A MII mCherry stably expressing control GFP (MII GFP) or ectopic WNT7B-MYC (MII WNT7B) were injected into the DoC of 48-hpf zebrafish embryos. Left: representative images of zebrafish at 6 days post-injection (dpi). Right: quantification of invasive cell cluster numbers in GFP or WNT7B-MYC expressing MCF10A MII cells injected zebrafish larvae. (B) Kaplan-Meyer analysis of overall survival of breast cancer datasets from Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (40); all subtypes, n = 1904; ER⁺ subjects, n = 1445; ER⁻ subjects, n = 429; luminal A subtype, n = 679; luminal B subtype, n = 461; HER2- subtype, n = 220; basal-like subtype, n = 199). Survival analysis was performed using a log-rank test. (C) Z-scored expression values of mRNA were obtained with cBioPortal (42,43). (***P < 0.001; n.s. not significant, Welch's t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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