FIGURE

Figure 9.

ID

ZDB-FIG-190723-1534

Publication

Eckert et al., 2019 - Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt

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Figure 9.

Inhibition of Wnt-signalling does not affect dorsal ventral axis specification. In situ hybridizations for bambia (a–f), vax2 (g–l) and pax2a (m–r) on LGK-974-treated embryos (d–f, j–l, p–r) and DMSO control embryos (a–c, g–i, m–o) at 17 hpf. Inhibitor treatment started at 13 hpf. No change of the expression pattern was found for bambia and vax2. Pax2a, however, was found expressed ectopic within the nasal lens-averted layer resulting from Wnt-signalling inhibition. Lateral view, nasal to the left; scale bar, 25 µm. For each condition, eight embryos were used; four to five of them were imaged.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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