FIGURE

Figure 7.

ID

ZDB-FIG-190723-1532

Publication

Eckert et al., 2019 - Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt

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Figure 7.

Induced bmp4 expression affects moprphogenesis and axis specification. In situ hybridizations for bambia (a–f), vax2 (g–l) and pax2a (m–r) in tg(hsp70:bmp4) (d–f, j–l, p–r) and control embryos (a–c, g–i, m–o) at 24 hpf after heat shock at 17 hpf. Note the extended bambia expression domain within the entire optic cup resulting from bmp4 induction, compared to the dorsal expression domain in the control. Vax2 expression is reduced after bmp4 induction compared to the control. Bmp4 induction also results in a reduced pax2a expression domain within the optic cup, while the pax2a expression domain in the optic stalk is enlarged. Lateral view, nasal to the left; scale bar, 25 µm. For each condition, eight embryos were used; four to five of them were imaged.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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