FIGURE

Figure 4

ID

ZDB-FIG-190723-104

Publication

Ohnesorge et al., 2019 - Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

Other Figures

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Figure 4

Identification and confirmation of Hit G5. (A)G5 was a promising hit identified in the screen of DIVERSet™ library plate #30238. (B) The chemical structure and chemical name (4-[4-(1H-benzimidazol-2-yl)phenoxy]aniline) of hit G5. (C) G5 shows a dose-dependent and robust reduction of primary hyaloid vessels at 10 and 20 μM. In addition, at higher doses treated larvae show no difference in survival rates and had only mild morphological changes compared to vehicle control treatments. (D) In contrast, G5 had no significant antiangiogenic effect in the ISV assay at the same range of concentrations. Data are means ± SD. Statistical significance calculated by t test and Mann Whitney test (*p < 0.05, **p < 0.01, ***p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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