FIGURE

Fig. 4

ID

ZDB-FIG-190703-40

Publication

Lazcano et al., 2019 - Knock-Down of Specific Thyroid Hormone Receptor Isoforms Impairs Body Plan Development in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Characterization of thraa and l-thrb+ crispants. (A)thraa and l-thrb+ crispants show diverse phenotypes with several degrees of body plan affectations as compared with wild-type at 3 dpf. Various phenotypes were observed due the mosaicism of the mutation. (B,C) Represent the percentage of normal, affected and deceased larvae after sgRNA and Cas9 treatment. (D) DNA sequence of sgRNA target site for CRISPR/Cas9 is denoted in gray, whereas PAM sequence is denoted in blue. Insertion-deletions (indels) are highlighted in yellow.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + CRISPR2-thrb
Knockdown Reagent:	CRISPR2-thrb
Observed In:	caudal fin whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)