FIGURE

Fig. 4

ID

ZDB-FIG-190626-59

Publication

Chrispell et al., 2018 - Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish

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Fig. 4

Recovery of the isolated cone-mass receptor potential to successive stimuli. (A) Representative ERG waveforms of APB-treated, dark-adapted larvae subjected to successive stimuli using a dual flash paradigm of a 20-ms flash of saturating white light (1000 cd/m²) with an interstimulus interval (ISI) of 2 s. Vertical black dotted lines indicate time of stimulus. (B) Data are plotted as the ratio of the maximum isolated cone mass receptor potential response of the second stimulus to that of the initial stimulus for ISIs ranging from 0.75 s to 5 s. A linear mixed model analysis of covariance found a significant effect of genotype when compared to wildtype for grk1b^−/− (F_[1,49] = 6.5; P = 0.0142) and grk7a^−/− (F_[1,33] = 36.6; P < 0.001). Inset, regression to the logarithmic linear part of the recovery kinetics.^{[ref. 7]} Error bars represent SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grk1b^nc201/nc201 grk7a^nc200/nc200
Observed In:	retinal cone cell cone photoresponse recovery
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.