FIGURE

Fig. 3

ID

ZDB-FIG-190620-6

Publication

Yang et al., 2019 - The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling

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Fig. 3

Loss of Zfpm1 led to trabeculation deformation in ventricle. (A) Confocal images (mid-sagittal optical sections) of larval hearts from control and Zfpm1^-/- animals at 10 dpf. (B) Left panels, confocal images (mid-sagittal optical sections) of larval hearts from control and Zfpm1^-/- animals at 12 dpf. Arrowheads indicated sites where trabecular is initiating. Right panel, quantification of number trabecular initiation site on section. 8 sections from control and 12 sections from Zfpm1^-/- fish were examined. Data are mean ± s.e.m. * p < 0.05. A and B, cardiomyocyte was labeled with Tg(myh7: GFP; myh7: DsRed-Nuc) transgenes. (C) Confocal projections of zebrafish juvenile hearts section at designated time points showing the abnormal trabeculation in Zfpm1^-/- animals. Cardiomyocyte was labeled with Tg(myh7: GFP) transgene. Scale bars, 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zfpm1^{nju204/nju204}; twu34Tg
Observed In:	cardiac ventricle cardiac ventricle heart trabecula formation trabecular layer
Stage Range:	Days 14-20 to Days 21-29

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 446(2), Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X., The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling, 142-150, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.