FIGURE

Fig. 7

ID

ZDB-FIG-190618-68

Publication

James et al., 2019 - Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Shank3abΔC mutants have a reduction in enteroendocrine cells. a Anterior (i.) and posterior (ii.) regions were sampled to quantify the number of enteric neurons (HuC, magenta), serotonin enteric neurons (HuC+/5-HT+, white, black arrowhead), and enteroendocrine cells (5-HT+, green, white arrow). Shank3abΔC mutants did not show a significant decrease in either b enteric neurons or c serotonin positive enteric neurons. d Serotonin positive enteroendocrine cells were significantly decreased in shank3abΔC mutants for both anterior and posterior regions. WT, n = 15;shank3abΔC ^+/−, n = 19; shank3abΔC ^−/−, n = 9. Scale bars represent 100 μm (a) and 50 μm (i, ii)

Expression Data

Antibodies:	Ab1-elavl Ab2-serotonin
Fish:	AB shank3a^umi101/+; shank3b^umi102/+ (AB) shank3a^{umi101/umi101}; shank3b^{umi102/umi102} (AB)
Anatomical Terms:	enteric nervous system serotonergic neuron enteric neuron enteroendocrine cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	shank3a^umi101/+; shank3b^umi102/+ (AB) shank3a^{umi101/umi101}; shank3b^{umi102/umi102} (AB)
Observed In:	enteroendocrine cell intestine serotonergic neuron
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol Autism